A Different Approach to Assess Oxidative Stress in Dengue Hemorrhagic Fever Patients Through The Calculation of Oxidative Stress Index

Authors

  • Edi Hartoyo Department of Pediatric, Ulin General Hospital/ Faculty of Medicine, Lambung Mangkurat University
  • Iskandar Thalib Research and Development Unit, Mutiara Bunda Mother and Child Hospital http://orcid.org/0000-0002-9022-757X
  • Cynthia Maharani Puspita Sari Research and Development Unit, Mutiara Bunda Mother and Child Hospital
  • Windy Yuliana Budianto Department of Pediatric Nursery, Faculty of Medicine, Lambung Mangkurat University
  • Eko Suhartono Department of Medical Chemistry/Biochemistry, Faculty of Medicine, Lambung Mangkurat University http://orcid.org/0000-0002-1239-6335

DOI:

https://doi.org/10.11594/jtls.07.03.08

Keywords:

Dengue Hemorrhagic Fever, Oxidative Stress, Oxidative Stress Index

Abstract

The objectives of this study were to determine the involvement of Oxidative Stress (OS) in the pathogenesis of dengue hemorrhagic fever (DHF) through the analysis of oxidative stress Index (OSI). The levels of malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) activity, and OSI were measured in 61 child dengue patients and (aged 6 months–18 years) with three different stages of DHF, i.e stage I, II, and III. The results show that the levels of MDA, SOD and CAT activity, and OSI significantly different between the group. The all parameters that investigated in this present study seems higher MDA level and OSI in the higher grade of DHF, except for SOD and CAT activity. From this result, it can be concluded that oxidative stress pathways might be involved in the pathomechanism of DHF and OSI might be used as a biomarker for OS and the severity in DHF patients.

References

Sitepu MS, Kaewkungwal J, Luplerdlop N et al. (2013) Temporal patterns and a disease forecasting model of den-gue hemorrhagic fever in Jakarta based on 10 years of surveillance data. The Southeast Asian Journal of Tropical Medicine and Public Health 44 (2): 206-217.

Kumar CM, Vyas KSK, Krishna YS (2017) Clinical profile of dengue fever with severe thrombocytopenia and its complications: A retrospective study at a tertiary care hos-pital in South India. International Journal of Research in Medical Sciences 5 (5): 1 – 5. doi: 10.18203/2320-6012.ijrms20171543.

Yee LY, Heryaman H, Faridah L (2017) The relationship between frequency of fogging focus and incidence of dengue hemorrhagic fever cases in Bandung in year 2010 – 2015. International Journal of Research in Medical Scienc-es 4 (2): 456 – 459. doi: 0.18203/2394-6040.ijcmph20170272.

Kamaruddin D, Sungkar S (2013) The trend of dengue hemorrhagic fever cases in Central Jakarta 2008-2010. The Trend of dengue hemorrhagic fever. eJournal Kedokteran Indonesia. 1 (1): 15 – 22. doi: 10.23886/ejki.1.1606.15-22.

Naseer F, Nazish A, Khan R et al. (2015) Dengue: An escalating problem of our society. Open Journal of Epidemiology 5 (1): 9 – 13. doi: 10.4236/ojepi.2015.51002.

Soundravally R, Sankar P, Bobby Z, Hoti SL (2008) Oxidative stress in severe dengue viral infection: Association of thrombocytopenia with lipid peroxidation. Platelets 19 (6): 447 – 454. 10.1080/09537100802155284.

Castro R, Pinzon HS, Alvis-Guzman N (2015) A systematic review of observational studies on oxidative/nitrosative stress involvement in dengue pathogenesis. Colombia Medica 46 (3): 135 – 143.

Castro-Orozco R, Alvis-Guzman NR (2016) Role of oxidative and nitrosative stress in dengue pathogenesis: A mini-review. Journal of Molecular and Genetic Medicine 10: 229. doi: 10.4172/1747-0862.1000229.

Hartoyo E, Thalib I, Suhartono E, Yunanto A (2016) Oxidative and chlorinative stress in children with dengue hemorrhagic fever. International Journal of Pharmaceutical and Clinical Reserach 8 (8): 1186 – 1191.

Kania N, Thalib I, Suhartono E. (2016) Chlorinative index in liver toxicity induced by iron. International Journal of Pharmaceutical and Clinical Reserach 8 (9): 1300 – 1304.

Udipi S, Ghugre P, Gokhale C (2012) Iron, oxidative stress and health. In: Dr. Volodymyr Lushchak eds. Oxidative stress - Molecular mechanisms and biological effects. doi: 10.5772/34975.

Allameh A, Amini-Harandi A, Osati-Ashtiani F, O’Brien PJ (2008) Iron overload induced apoptotic cell death in isolated rat hepatocytes mediated by reactive oxygen species. Iranian Journal of Pharmaceutical Research 7 (2): 115 – 121.

Sevcikova M, Modra H, Slaninova A, Svobodova Z (2011) Metals as a cause of oxidative stress in fish: A review. Vet-erinarni Medicina 56 (11): 537 – 546.

Suhartono E, Triawanti, Leksono AS, Djati MS (2015) Effects of cadmium exposure on lipid peroxidation and chlorinative stress of rat kidney. The Journal Experimental Life Science 5 (1): 1 – 5. doi: 10.21776/ub.jels.2015.005.01.01.

Suhartono E, Iskandar, Hamidah S, Arifin YF (2015) Phytochemical constituents analysis and neuroprotective effect of leaves of Gemor (Nothaphoebe coriacea) on cadmium-induced neurotoxicity in rats: An in-vitro study. International Journal of Toxicological and Pharmacological Re-search 7 (6): 297 – 302.

Lestarisa T, Alexandra FD, Jelita H, Suhartono E (2106) Peroxidative index: A new marker in kidney toxicity induced by mercury. Journal of Toxicological and Pharma-cological Research 8: 440 – 444.

Ivanov AV, Bartosch B, Isaguliants MG (2107) Oxidative stress in infection and consequent disease. Oxidative Medicine and Cellular Longevity 2017 (2017). doi: 10.1155/2017/3496043.

Seet RCS, Lee CYJ, Lim ECH et al. (2009) Oxidative damage in dengue fever. Free Radical Biology and Medicine 47 (4): 375 – 380. doi: 10.1016/j.freeradbiomed.2009.04.035.

Gill L, Martinez G, Tapanes R, Castro O, Gonzalez D, Bernardo L, Vasquez S, Kouri G, Guzman M (2004) Oxidative stress in adult dengue patients. The American Socie-ty of Tropical Medicine and Hygiene 71 (5): 652 – 657.

Suwanprinya L, Morales NP, Sanvarinda P et al. (2016) Dengue virus-induced reactive oxygen species production in rat microglia cells. Japanese Journal of Infectious Diseases 70 (4): 383 – 387. doi: 10.7883/yoken.JJID.2016.236.

Rasool M, Malik A, Khan KM et al. (2015) Assessment of biochemical and antioxidative status in patients suffering from dengue fever. Journal of Huazhong University of Science and Technology 35 (3): 411 – 418. doi: 10.1007/s11596-015-1446-x.

Downloads

Published

2017-09-11

Issue

Vol. 7 No. 3 (2017)

Section

Articles

License

The work has not been published before (except in the form of an abstract or part of a published lecture or thesis) and it is not under consideration for publication elsewhere. When the manuscript is accepted for publication in this journal, the authors agree to automatic transfer of the copyright to the publisher.

Creative Commons License
Journal of Tropical Life Science is licensed under Creative Commons Attribution-NonCommercial 4.0 International License