The Correlation of Regulatory T (TReg) and Vitamin D3 in Pediatric Nephrotic Syndrome

Authors

  • Yunika Nurtyas Medical Faculty, Brawijaya University, Malang 65145, Indonesia
  • Krisni Subandiyah
  • Loeki Enggar Fitri

DOI:

https://doi.org/10.11594/jtls.08.01.08

Keywords:

Nephrotic syndrome, vitamin D, TReg

Abstract

Nephrotic syndrome (NS) is an autoimmune disease that correlates to the imbalance of regulatory T cells (TReg). This study was aimed to investigate the effect of vitamin D as adjuvant therapy of TReg population in pediatric nephrotic syndrome. This study was designed randomized clinical trial, double blind, with pre- and post-test control groups involving 15 subjects newly diagnosed with NS. Subjects were divided into 2 groups, namely K1 for group treated with prednisone+vitamin D and K2 group for prednisone treatment only. The population of TReg in peripheral blood mononuclear cells (PBMC) was analyzed using flowcytometry. Vitamin D serum level was measured through ELISA method. Results showed that there was a significant elevation of TReg (independent t-test, p = 0.010) in K1 group, which was higher than in K2 group. The Pearson test in the K1 group showed that vitamin D level was positively correlated with TReg (p = 0.039, r = 0.779).

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Published

2018-01-05

Issue

Vol. 8 No. 1 (2018)

Section

Articles

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