Correlation of Interleukin-10, Superoxide Dismutase (SOD), and Malondialdehyde (MDA) Levels with HbA1c in Pediatric Type 1 Diabetes Mellitus

Authors

  • Lina Astari Department of Pediatric, Saiful Anwar General Hospital, Malang, Indonesia; Master Program of Biomedical Science, Medical Faculty of Brawijaya University, Malang, Indonesia
  • Haryudi Cahyono Department of Pediatric, Saiful Anwar General Hospital, Malang, Indonesia
  • Edi Widjajanto Department of Pediatric, Saiful Anwar General Hospital, Malang, Indonesia

DOI:

https://doi.org/10.11594/jtls.07.03.15

Keywords:

Type 1 diabetes mellitus, superoxide dismutase, malondialdehyde, interleukin 10, HbA1c.

Abstract

Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by pancreatic β-cell destruction and considered to be correlated with oxidative stress. This study aimed to investigate the association of oxidative stress [superoxide dismutase (SOD) and malondialdehyde (MDA) levels], inflammation [interleukin 10 (IL-10)], and glycemic control (HbA1c) in pediatric T1DM patients. This study included 25 T1DM subjects and 25 healthy control subjects and was designed as a cross- sectional study. SOD, MDA, and IL-10 levels were measured by ELISA. We obtained that that IL-10 and SOD levels were significantly decreased in the T1DM group, but MDA and HbA1c levels were significantly elevated in the T1DM group. IL-10 levels were positively correlated with SOD levels and negatively correlated with MDA and HbA1c. SOD levels were negatively correlated with HbA1c levels. MDA was positively correlated with HbA1c levels. IL-10 and SOD levels were significantly decreased, but MDA and HbA1c levels were significantly elevated in the T1DM group.

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Published

2017-09-30

Issue

Vol. 7 No. 3 (2017)

Section

Articles

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