Fecal Calprotectin Level of Breast Milk-Formula vs Formula Feeding in Preterm and Low Birth Weight Neonates with Necrotizing Enterocolitis

Authors

  • Ditya Arisanti Department of Pediatric, Saiful Anwar Hospital
  • Satrio Wibowo Department of Pediatric, Saiful Anwar Hospital, Malang

Keywords:

Breast milk, formula, fecal calprotectin, necrotizing enterocoliti

Abstract

Necrotizing enterocolitis (NE) is inflammatory disease and its prevalence was increase in preterm and low birth weight (LBW) neonates. This study was aimed to investigate the differences of fecal calprotectin level in breast milk-formula vs formula feeding infants in preterm and low birth weight neonates with necrotizing enterocolitis. There are 32 preterm and LBW neonates with NE were divided into two group (breast milk-formula and formula only feeding group). Fecal calprotectin level was measured using ELISA method. This study showed that fecal calprotectin level in breast milk-formula feeding group was insignificantly lower as compared to formula feeding group (independent t-test, p = 0.503). Further analysis showed that fecal calprotectin level was negatively correlated with patient’s outcome (Spearman correlation test, p = 0.03, r = 0.512). We concluded that fecal calprotectin level in breast milk-formula feeding group was insignificantly lower as compared to formula feeding only group in preterm and low birth weight neonates diagnosed with necrotizing enterocolitis. There was negative correlation between fecal calprotectin level and patient’s outcome.

References

Neu J, Walker WA (2011) Necrotizing enterocolitis. The New England Journal of Medicine 364: 255-264. doi: 10.1056/NEJMra1005408.

Ahle M, Drott P, Andersson RE (2013) Epidemiology and trends of necrotizing enterocolitis in Sweden: 1987-2009. Pediatrics 132 (2): e443 – e451. doi:10.1542/peds.2012-3847.

Henry MCW, Moss RL (2009) Necrotizing enterocolitis. Annual Review Medicine 60: 111 – 124. doi: 10.1146/annurev.med.60.050207.092824.

Maheshwari A, Corbin L, Schelonka R (2011) Neonatal necrotizing enterocolitis. Research and Reports in Neonatology 1: 39 – 53. doi: 10.2147/RRN.S23459.

Gordon P, Christensen R, Weitkamp JH, Maheshwari A (2012) Mapping the new world of necrotizing enterocolitis (NEC): Review and opinion. The E-Journal of Neonatology Research 2 (4): 145 – 172.

Chu A, Hageman JR, Caplan MS (2013) Necrotizing enterocolitis: Predictive markers and preventive strategies. Neoreviews 14 (3): e113 - e120. doi: 10.1542/neo.14-3-e113.

Grave GD, Nelson SA, Walker WA et al. (2007) New therapies and preventive approaches for necrotizing enterocolitis: Report of a research planning workshop. Pediatric Research 62: 510 – 514. doi: 10.1203/PDR.0b013e318142580a.

Olariu L, Olariu G, Ognean L et al. (2014) Necrotizing enterocolitis in preterm infants with gestational age < 32 weeks in Rumania: Incidence and risk factors. Jurnalul Pediatrului 17: 36 – 41.

Hunter CJ, Upperman JS, Ford HR, Camerini V (2008) Understanding the susceptibility of the premature infant to necrotizing enterocolitis (Nec). Pediatric Research 63: 117 – 123. doi: 10.1203/PDR.0b013e31815ed64c.

Good M, Sodhi CP, Hackam DJ (2014) Evidence-Based feeding strategies before and after the development of necrotizing enterocolitis. Expert Review of Clinical Immunology 10 (7): 875 –

doi: 10.1586/1744666X.2014.913481.

Young C, Sharma R, Handfield M et al. (2009) Biomarkers for infants at risk for necrotizing enterocolitis: Clues to prevention?. Pediatric Research 65: 91r - 97r. doi: 10.1203/PDR.0b013e31819dba7d.

Markel TA, Engelstad H, Poindexter BB (2014) Predicting disease severity of necrotizing enterocolitis: how to identify infants for future novel therapies. Journal of Clinical Neonatology 3 (1): 1 – 9. doi: 10.4103/2249-4847.128717.

Ng PC (2014) Biomarkers of necrotising enterocolitis. Seminars in Fetal and Neonatal Medicine 19 (1): 33 – 38. doi: 10.1016/j.siny.2013.09.002.

Dhas B, Bhat V, Gane B (2012) Role of calprotectin in infection and inflammation. Current Pediatric Research 16 (2): 83 – 94.

Aydemir O, Aydemir C, Sarikabadayi YU et al. (2012) Fecal calprotectin levels are increased in infants with necrotizing enterocolitis. Journal of Maternal-Fetal and Neonatal Medicine 25 (11): 2237 – 2241. doi: 10.3109/14767058.2012.684172.

Vaos G, Kostakis ID, Zavras N, Chatzemichael A (2013) The Role of calprotectin in pediatric disease. Biomed Research International: 542363. doi: 10.1155/2013/542363.

Stout G, Lamber DK, Baer VL et al. (2008) Necrotizing enterocolitis during the first week of life. Journal of Perinatology 28: 556 – 560. doi: 10.1038/jp.2008.36.

Zoppelli L, Guttel C, Bittrich HJ et al. (2012) Fecal calprotecti concentration in premature infants have a lower limit and show postnatal and gestational age dependence. Neonatology 102: 68 – 74. doi: 10.1159/000337841.

Sidauruk RJM, Amir I, Kadim M, Said M (2014) Faktor risiko yang mempengaruhi kolonisasi mikroflora saluran cerna neonatus kurang bulan dengan enterokolitis nekrotikan. Sari Pediatri 15 (6): 353 – 360. doi: 10.14238/sp15.6.2014.353-60.

Josefsson S, Bunn SK, Domellöf M (2007) Fecal calprotectin in very low birth weight infants. Journal of Pediatric Gastroenterology and Nutrition 44 (4): 407 – 413. doi: 10.1097/MPG.0b013e3180320643.

Kapel N, Campeotto F, Kalach N et al. (2010) Fecal calprotectin in term and preterm neonates. Journal of Gastroenterology Hepatology and Nutrition 51 (5): 542 – 547. doi: 10.1097/MPG.0b013e3181e2ad72.

Campeotto F, Baldassarre M, Butel MJ et al. (2009) Fecal calprotectin: Cutoff values for identifying intestinal distress in preterm infants. Journal of Pediatric Gastroenterology and Nutrition 48 (4): 507 – 510. doi: 10.1097/MPG.0b013e318186c4a6.

El Frargy MS, Hassan AM (2014) The Effect of probiotics supplementation on fecal calprotectin as an early marker of neonatal enteropathy. Journal of American Science 10 (8): 209 – 213.

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Published

2018-11-09

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