Apigenin, an Anticancer Isolated from Macaranga gigantifolia Leaves

Authors

  • Sofa Fajriah Research Center for Chemistry, Indonesian Institute of Sciences (LIPI), Kawasan PUSPIPTEK, Serpong, Tangerang Selatan, Banten, 15314
  • Megawati Megawati Research Center for Chemistry, Indonesian Institute of Sciences (LIPI), Kawasan PUSPIPTEK, Serpong, Tangerang Selatan, Banten, 15314
  • Akhmad Darmawan Research Center for Chemistry, Indonesian Institute of Sciences (LIPI), Kawasan PUSPIPTEK, Serpong, Tangerang Selatan, Banten, 15314

DOI:

https://doi.org/10.11594/jtls.06.01.02

Abstract

Apigenin, a flavonoid compound has been isolated from the ethyl acetate fraction of methanol extract of Macaranga gigantifolia leaves. Isolation and purification of apigenin conducted using chromatographic method, and chemical structure characterized based on spectroscopic data. In vitro anticancer activity test against murine leukemia P-388 cell line showed potential activity with IC50 14.13 μg/mL.

Key words: apigenin, flavones, Macaranga gigantifolia, anticancer, murine leukemia P-388 cell line.

References

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Published

2016-03-04

Issue

Vol. 6 No. 1 (2016)

Section

Articles

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