Isolation of an Anti-Cancer Asperuloside from Hedyotis corymbosa L.

Authors

  • Nina Artanti Research Center for Chemistry-Indonesian Institute of Sciences (RCChem LIPI)
  • Muhammad Hanafi Research Center for Chemistry-Indonesian Institute of Sciences (RCChem LIPI)
  • Rina Andriyani Research Center for Chemistry-Indonesian Institute of Sciences (RCChem LIPI)
  • Vienna Saraswaty Research Center for Chemistry-Indonesian Institute of Sciences (RCChem LIPI)
  • Linar Zalinar Udin Research Center for Chemistry-Indonesian Institute of Sciences (RCChem LIPI)
  • Puspa D Lotulung Research Center for Chemistry-Indonesian Institute of Sciences (RCChem LIPI)
  • Ken Ichi Fujita Material Sciences, Faculty of Science, Osaka City University - Japan
  • Yoshinosuke Usuki Material Sciences, Faculty of Science, Osaka City University - Japan

DOI:

https://doi.org/10.11594/jtls.05.02.06

Abstract

Hedyotis corymbosa, with local name rumput mutiara, is an anti-inflammatory, anti-cancer and hepatoprotective traditional medicine.  The ethanol extract of H. corymbosa L. shows inhibitory activity to human YMB-1 breast cancer cell line with an IC50 of 6.51 mg/ml.  The methylene chloride fraction shows a potential cytotoxic activity with an IC50 of 2.75 mg/ml.  To obtain a lead compound, the extract was further purified by column chromatography. A pure compound is obtained which shows inhibitory activities against YMB-1, HL60 and KB human cell lines with IC50 values of 0.7; 11.0 and 104.2 mg/ml, respectively.  Based on the 1D and 2D FT-NMR data, the isolated compound is an asperuloside.

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Published

2015-06-29

Issue

Vol. 5 No. 2 (2015)

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Articles

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