Vitamin D Profile and Disease Activity of JIA During Pandemic Covid-19
Vitamin D Profile and Disease Activity of JIA
DOI:
https://doi.org/10.11594/jtls.12.02.05Keywords:
Vitamin D, JIA, disease activity, pandemic Covid-19Abstract
Vitamin D (25-Hydroxyvitamin D3 [25(OH)D3]) has an important role in the immune
system. This study aimed to assess the relationship between 25-Hydroxyvitamin D3
and disease activity in Indonesian children with Juvenile Idiopathic Arthritis (JIA)
during pandemic Covid-19. A 12-week randomized control trial was undertaken at
Saiful Anwar Hospital between June and September 2021. JIA patients are divided
into two groups. The control group (CG), without supplementation, and the treatment
group (TG) got a high dose of oral cholecalciferol 2000 IU/day. Serum levels of
25(OH)D3 were measured using an enzyme-linked immunosorbent assay (ELISA).
Comparison between serum 25(OH)D3 levels and JIA subtypes, peripheral blood Creactive protein (CRP), erythrocyte sedimentation rate (ESR), and Juvenile Arthritis
Disease Activity Score (JADAS-27 Score) were analyzed using SPSS. There was a
significant increase in serum 25(OH)D3 levels in treatment group (mean: 27.38 ± 6.39
ng/ml vs 42.26 ± 10.95 ng/ml; P=0.000). The JADAS-27 score significantly decrease
in treatment group (14.60 ± 4.04 vs 6.24 ± 1.96; p= 0.000). Serum 25(OH)D3 showed
a significant correlation with the JADAS-27 score. The levels of 25(OH)D3 are
significantly decreased in children with JIA. Decreased 25(OH)D3 levels may be
associated with the etiopathogenesis of JIA. Vitamin D levels have correlations with
disease activity. Adjunctive treatment of cholecalciferol improves the disease activity
in JIA patients.
Keywords: Disease activity, JIA, Pandemic Covid-19, Vitamin D
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