Differences in the Levels of Interleukin-1β (IL-1β) and Interleukin-1 Receptor Antagonist (IL-1ra) in Children with Status Epilepticus and Febrile Seizure

Authors

  • Fita Shofiyah Magister Program in Biomedical Sciences, Faculty of Medicine, University of Brawijaya Malang
  • Masdar Muid Department of Pediatric, Saiful Anwar General Hospital, Malang
  • Hidayat Sujuti Biochemistry laboratory, Faculty of Medicine, University of Brawijaya Malang

DOI:

https://doi.org/10.11594/jtls.07.03.05

Keywords:

Febrile seizure, IL-1β, IL-1ra, status epilepticus.

Abstract

Proinflammatory cytokines are elevated in status epilepticus and febrile seizure and associated with tissue damage. This study aimed to investigate the differences in interleukin 1 beta (IL-1β) and interleukin 1 receptor agonist (IL-1ra) levels in status epilepticus as compared with febrile seizure and febrile. This cross-sectional study was designed to include 45 subjects divided equally into three groups (status epilepticus, febrile seizure, and febrile). Both IL-1β and IL-1ra were measured by using an ELISA method. Results showed that IL-1β levels were significantly higher in the status epilepticus group as compared with the febrile seizure and febrile groups (p < 0.05). IL-1ra levels in the status epilepticus group were significantly lower compared with the febrile seizure group (p = 0.04). Consistently, the IL-1β/IL-1ra ratio in the status epilepticus group was significantly higher as compared with the febrile seizure group (p = 0.01). We concluded that IL-1β and the IL-1β/IL-1ra ratio were significantly higher in status epilepticus. IL-1ra levels were significantly higher in the febrile seizure group.

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Published

2017-09-11

Issue

Vol. 7 No. 3 (2017)

Section

Articles

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